Protein Crystallography and Structural Biology. Cooperation with Relarted Sciences and Future Plans. Structural Biology and Bioinformatics.
نویسندگان
چکیده
منابع مشابه
Neutron Protein Crystallography. Hydrogen- and Hydration-sensitive Structural Biology
Neutron protein crystallography (NPC) has not substantially contributed to the determination of the folding structures of biological macromolecules. It takes the next step beyond the folding structure of proteins. This paper demonstrates how hydrogen atoms can be seen by NPC and how NPC can explore protonation and deprotonation of amino acid residues, hydration structures, and hydrogen-to-deute...
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Proteins are the main perpetrators of most cellular tasks. However, they seldom act alone and most biological processes are carried out by macromolecular assemblies and regulated through a complex network of protein-protein interactions. Thus, modern molecular and cell biology no longer focus on single macromolecules but now look into complexes, pathways or even entire organisms. The many genom...
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Protein crystallography, the main experimental method of structural biology, has undergone in the recent past three revolutionary changes leading to its unexpected renaissance. They were connected with (i) the introduction of synchrotron radiation sources for X-ray diffraction experiments, (ii) implementation of Se-Met multiwavelength anomalous diffraction (MAD) for phasing, and (iii) initiatio...
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In the late 1970s, macromolecular crystallography at NIST began with collaboration between NIST and NIH to establish a single-crystal neutron diffractometer. This instrument was constructed and employed to solve a number of crystal structures: bovine ribonuclease A, bovine-ribonuclease-uridine vanadate complex, and porcine insulin. In the mid 1980s a Biomolecular Structure Group was created est...
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The techniques of structural biology currently play an important role in the development of novel therapeutic agents including cancer chemotherapies. X-ray crystallography has proved to be a particularly powerful tool for both the discovery of novel compounds and their subsequent development. In this review of the literature, the steps involved in the determination of a crystal structure will b...
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ژورنال
عنوان ژورنال: Nihon Kessho Gakkaishi
سال: 1996
ISSN: 0369-4585,1884-5576
DOI: 10.5940/jcrsj.38.111